BIO-INSPIRED TISSUE ADHESIVE CHITOSAN/PLURONIC COMPOSITE HYDROGEL

摘要：

Herein, we demonstrate novel tissue adhesive, injectable and thermo-sensitive chitosan/pluronic composite hydrogels inspired by the unusual adhesion used by mussels. We found that the conjugation of catechol moieties, the key components of mussel adhesion, is highly beneficial for (1) chemical crosslinking of chitosan and pluronic, and (2) rapid and strong adhesion of the hydrogels on soft tissues and mucous layers. These novel tissue adhesive chitosan/pluronic based hydrogels are expected to be used for drug delivery, tissue engineering, and tissue adhesives to arrest bleeding.

关键词： tissue adhesive hydrogel haemostasis in-situ gelation chitosan catechol

作者: Ji Hyun Ryu Yu-han Lee Won Ho Kong Taek Gyoung Kim Tae Gwan Park

作者单位: Graduate School of Nanoscience and Technology (GSNT), Korea Advanced Institute of Science and Techno Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST),Daejeo Graduate School of Nanoscience and Technology (GSNT), Korea Advanced Institute of Science and Techno

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 534-536

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）