UNDERSTANDING THE ROLE OF THE C3-HYDROXYL GROUP IN GLYCYRRHETINIC ACID ON LIVER TARGETING

摘要：

Glycyrrhetinic acid (GA)-modified chitosan/poly(ethylene glycol) nanoparticles were prepared, in which GA as a liver targeting ligand was introduced at different sites: the C3-hydroxyl group (CTS/PEG-GA(h) NPs) or the C30-carboxyl group (CTS/PEG-GA(c) NPs). Their characteristics, especially the liver targeting ability, were compared. Results showed that there is no significant difference between the CTS/PEG-GA(c) NPs and the CTS/PEG-GA(h) NPs in their ability to target the liver, indicating that the C3-hydroxyl group in GA has little influence on the targeting ability.

关键词： glycyrrhetinic acid chitosan poly(ethylene glycol) liver targeting

作者: Qin Tian Xiuhua Wang Wei Wang Chuangnian Zhang Zhi Yuan Xuesi Chen

作者单位: Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 537-539

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）