RAPIDLY PHOTO-CROSSLINKED FUNCTIONAL BIODEGRADABLE HYDROGELS

摘要：

Rapidly gelling functional biodegradable hydrogels were prepared through UV crosslinking of poly(D,L-lactide-co-acryloyl carbonate)-poly(ethylene glycol)-poly(D,L-lactide-co-acryloyl carbonate) (PLAC-PEG-PLAC) triblock copolymers, in which the acryloyl groups were amenable to the Michael-type conjugate addition with thiol-containing bioactive molecules such as cysteine and arginine-glycine-aspartic acid-cysteine (RGDC) peptide under mild conditions. Notably, the functionalization was nearly quantitative. The swelling/degradation studies showed that hydrogels with less LA units and more AC units had longer degradation times. The combination of Michael-addition reaction with photopolymerization appears to be an elegant approach to obtain injectable bioactive hydrogels.

关键词： hydrogels photopolymerization biodegradable RGDC functional bioactive tissue engineering

作者: Rong Wang Chao Deng Ru Cheng Fenghua Meng Jan Feijen Zhiyuan Zhong

作者单位: Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Organic Chemistry, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 546-548

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）