THE POTENTIAL FOR BLOOD VESSEL ENGINEERING OF PHSRN-MODIFIED POLYMER: HUVEC CELL AFFINITY EVALUATION AND INTEGRIN-MEDIATED MECHANISM STUDY

摘要：

To investigate the role of the peptide PHSRN in cell adhesion, PHSRN-and GRGDS-containing polymers (P-PN5 and P-GS5, respectively) were synthesized by modification of poly(D,L-lactide-co-beta-malic acid) (PLMA) with the corresponding peptides. The cell affinities of the modified polymers and the integrin-mediated mechanism of the cell-substrate interaction were evaluated. The findings suggest that PHSRN is capable of mediating the adhesion and growth of human umbilical vein endothelial cells independently and that PHSRN-modified polymers might be used as biologically compatible materials.

关键词： peptides cell affinity binding force binding capacity biomimetic material

作者: Wei Wang Yuan Liu Jun Wang Zhi Yuan Deling Kong

作者单位: Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistr Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai Unive

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 549-551

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）