BASIC PROPERTIES OF ALGINATE/CHITOSAN MICROCAPSULE SURFACES AND THEIR INTERACTION WITH PROTEINS

摘要：

Surface properties such as morphology, composition, wet ability and charge of alginate/chitosan (ACA) microcapsules were analyzed. The effects of surface properties on fibrinogen adsorption onto ACA microcapsules and on its in vivo biocompatibility were then evaluated. The results showed that the increase in both surface roughness and zeta potential resulted in an increase in the amount and conformational change of fibrinogen adsorbed. Microcapsules with rougher surface and higher zeta potential implanted into the peritoneal cavities of mice elicited a more severe foreign body response.

关键词： microcapsule surface property interaction protein cell

作者: Hongguo Xie Weiting Yu Xiudong Liu Weiyang Xie Guojun Lv Feng Wang Xiaojun Ma

作者单位: Laboratory of Biomedical Material Engineering, Biotechnology Division, Dalian Institute of Chemical College of Environment and Chemical Engineering, Dalian University, Dalian Economic Technological De Laboratory of Optical Fabrication and Coating, Dalian Institute of Chemical Physics, Chinese Academy

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 555-557

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）