LOCALLY INFUSED GENE CONTAING NANOPARTICLES TO INHIBIT RABBIT INTIMAL HYPERPLASIA

摘要：

Percutaneous transluminal coronary angioplasty (PTCA) is one of the most effective treatments for atherosclerosis, but a long-term curative effect is greatly prohibited by restenosis. Antisense monocyte chemotactic protein-1 (A-MCP-1) plays an important role in the restenosis process. In this study, A-MCP-1 nanoparticles were prepared from poly(lactic-co-glycolic acid) (PLGA) copolymer and investigated for local gene therapy.

关键词： PLGA nanoparticles A-MCP-1 gene therapy PCR

作者: Jing Yang Yong Zeng Wenling Zhu Cunxia Song Mei Yue

作者单位: Institute of Biomedical Engineering, Chinese Academy of Medical Sciences,Bai Di road No.236, Nan Kai Department of Cardiology, Peking Union Medical College Hospital, Beijing 100730, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 570-572

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）