PREPARATION AND CHARACTERIZATION OF A NEW COPOLYMER POLY(L-GLUTAMIC ACID)-BLOCK-POLY (LACTIC-CO-GLYCOLIC ACID)

摘要：

A novel biodegradable diblock copolymer poly(L-lactic-co-glycolic acid)-block-poly(L-glutamic acid) (PLGA-b-PGA) was synthesized by a macromolecular coupling reaction. This synthetic strategy simplified a former synthesis process of polypeptide-poly(L-lactic acid) (PLA). The copolymer exhibited high pH response and the copolymer aggregates underwent four stages with increase of pH: a disorganized form, micelles, semi-vesicles with thick walls and vesicles. Such a pH-dependent self-assembly process is promising for drug delivery and bio-applications.

关键词： poly(L-lactic-co-glycolic acid)-block-poly(L-glutamic acid) copolymers pH dependence drug delivery

作者: Yanan Yang Yecan Zheng Xiuli Zhuang Xuesi Chen

作者单位: Chemical Engineering Institute, Changchun University of Technology, Changchun 130012, China,State Ke State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 573-575

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）