EFFECT OF NANO-STRUCTURED POLYMER SURFACES ON OSTEOBLAST ADHESION AND PROLIFERATION

摘要：

Controlling cell-matrix interactions in the nanometer size scale is important for regulating cell phenotype in tissue engineering. We hypothesized that adhesion and proliferation of osteoblasts could be influenced by varying the nano-structured surfaces. Poly(styrene-b-ethylene oxide) diblock copolymers were used to generate the nano-structured surfaces. As PS domain size decreased, cell proliferation was enhanced. This approach to controlling cell phenotype by varying the surface structure in the nanometer size scale could be useful for designing novel scaffolds in tissue engineering applications.

关键词： cell-matrix interaction osteoblast nano-scale

作者: Soo-Jeong Yeon Jin-Wook Lee Jae-Won Lee Young-Je Kwark Seung Hyun Kim Kuen Yong Lee

作者单位: Department of Bioengineering, Hanyang University, Seoul 133-791, Korea Division of Nano-Systems Engineering, Inha University, Incheon 402-751, Korea Department of Organic Materials and Fiber Engineering, Soongsil University, Seoul 156-743, Korea

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 579-580

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）