ACTIVE TARGETING AND FLUORESCENCE-LABELED MICELLES: PREPARATION,CHARACTERIZATION AND CELLULAR UPTAKE EVALUATION

摘要：

A novel amphipathic copolymer propargyl poly(ethylene glycol)-b-poly(L-lactide) (propargyl-PEG-PLA) was synthesized successfully. By mixing with another amphipathic block copolymer poly(ethylene glycol)-b-poly(L-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/Rhodamine) MPEG-P(LA-co-DHP/Rh), fluorescence-labeled hybrid micelles were obtained. Transferrin as a targeting ligand was immobilized onto the surface of the hybrid micelles through the click reaction. The intracellular uptake of the hybrid micelles by MCF-7 cell line was increased after conjugation with transferrin compared with the unconjugated ones.

关键词： active targeting copolymer transferrin hybrid micelles intracellular uptake

作者: Jun Yue Shi Liu Guojun Mo Rui Wang Xiabin Jing

作者单位: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 581-583

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）