SYNTHESIS OF GLUCOSE-SENSITIVE BLOCK GLYCOPOLYMERS BASED ON PHENYLBORONIC ACID VIA RAFT POLYMERIZATION

摘要：

A novel phenylboronic acid terminated amphiphilic glycopolymer was prepared by RAFT polymerization without any protection and deprotection procedure, and characterized by IR, 13C NMR and thermal analysis. The obtained glycopolymers comprised of a lactose-carrying block which could improve the biocompatibility of the phenylboronic acid groups and a phenylboronic acid-functionalized block which was glucose-responsive. The glycopolymers could easily self-assemble into nanoparticles (NPs) in aqueous solution. The NPs presented good glucose sensitivity, which makes them potential carries for controlled insulin delivery.

关键词： RAFT polymerization phenylboronic acid glucose sensitivity

作者: Cui Cheng Xinge Zhang Yanxia Wang Chaoxing Li

作者单位: Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 599-601

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）