Sparse Unbiased Analysis of Anatomical Variance in Longitudinal Imaging
(0) We present a new algorithm for reliable, unbiased, multivariate longitudinal analysis of cortical and white matter atrophy rates with penalized statistical methods. The pipeline uses a step-wise approach to transform and personalize template information first to a single-subject template (SST) and then to the individuals time series data. The first stream of information flows from group template to the SST; the second flows from the SST to the individual time-points and provides unbiased, prior-based segmentation and measurement of cortical thickness. MRI-bias correction, consistent longitudinal segmentation, cortical parcellation and cortical thickness estimation are all based on strong use of the subject-specific priors built from initial diffeomorphic mapping between the SST and optimal group template. We evaluate our approach with both testretest data and with application to a driving biological problem. We use testretest data to show that this approach produces (a) zero change when the retest data contains the same image content as the test data and (b) produces normally distributed, low variance estimates of thickness change centered at zero when test-retest data is collected near in time to test data. We also show that our approach—when combined with sparse canonical correlation analysis—reveals plausible, significant, annualized decline in cortical thickness and white matter volume when contrasting frontotemporal dementia and normal aging.
Brian Avants Philip A.Cook Corey McMillan Murray Grossman Nicholas J.Tustison Yuanjie Zheng James C.Gee
Depts.of Radiology and NeurologyUniversity of PennsylvaniaPhiladelphia, PA 19104-6389 Depts.of Radiology and Neurology University of Pennsylvania Philadelphia, PA 19104-6389
国际会议
北京
英文
324-331
2010-09-01（万方平台首次上网日期，不代表论文的发表时间）