In vivo Human 3D Cardiac Fibre Architecture: Reconstruction Using Curvilinear Interpolation of Diffusion Tensor Images
In vivo imaging of the cardiac 3D fibre architecture is still a challenge, but it would have many clinical applications, for instance to better understand pathologies and to follow up remodelling after therapy. Recently, cardiac MRI enabled the acquisition of Diffusion Tensor images (DTI) of 2D slices. We propose a method for the complete 3D reconstruction of cardiac fibre architecture in the left ventricular myocardium from sparse in vivo DTI slices. This is achieved in two steps. First we map non-linearly the left ventricular geometry to a truncated ellipsoid. Second, we express coordinates and tensor components in Prolate Spheroidal System, where an anisotropic Gaussian kernel regression interpolation is performed. The framework is initially applied to a statistical cardiac DTI atlas in order to estimate the optimal anisotropic bandwidths. Then, it is applied to in vivo beating heart DTI data sparsely acquired on a healthy subject. Resulting in vivo tensor field shows good correlation with literature, especially the elevation (helix) angle transmural variation. To our knowledge, this is the first reconstruction of in vivo human 3D cardiac fibre structure. Such approach opens up possibilities in terms of analysis of the fibre architecture in patients.
Nicolas Toussaint Maxime Sermesant Christian T.Stoeck Sebastian Kozerke Philip G.Batchelor
King’s College London, Imaging Sciences, London, UK INRIA, Asclepios Research Group, Sophia Antipoli King’s College London, Imaging Sciences, London, UK INRIA, Asclepios Research Group, Sophia Antipoli ETH Zurich, Institute for Biomedical Engineering, Switzerland King’s College London, Imaging Sciences, London, UK ETH Zurich, Institute for Biomedical Engineering King’s College London, Imaging Sciences, London, UK
国际会议
北京
英文
418-425
2010-09-01（万方平台首次上网日期，不代表论文的发表时间）