MRI-Guided Robotic Prostate Biopsy: A Clinical Accuracy Validation
Prostate cancer is a major health threat for men. For over five years, the U.S. National Cancer Institute has performed prostate biopsies with a magnetic resonance imaging (MRI)-guided robotic system. Purpose: A retrospective evaluation methodology and analysis of the clinical accuracy of this system is reported. Methods: Using the pre and post-needle insertion image volumes, a registration algorithm that contains a two-step rigid registration followed by a deformable refinement was developed to capture prostate dislocation during the procedure. The method was validated by using three-dimensional contour overlays of the segmented prostates and the registrations were accurate up to 2 mm. Results: It was found that tissue deformation was less of a factor than organ displacement. Out of the 82 biopsies from 21 patients, the mean target displacement, needle placement error, and clinical biopsy error was 5.9 mm, 2.3 mm, and 4 mm, respectively. Conclusion: The results suggest that motion compensation for organ displacement should be used to improve targeting accuracy.
Helen Xu Andras Lasso Siddharth Vikal Peter Guion Axel Krieger Aradhana Kaushal Louis L.Whitcomb Gabor Fichtinger
Queen’s University, Kingston, Canada National Institutes of Health, Bethesda, USA Sentinelle Medical Inc., Toronto, Canada Johns Hopkins University, Baltimore, USA Queen’s University, Kingston, Canada Johns Hopkins University, Baltimore, USA
国际会议
北京
英文
383–391
2010-09-01（万方平台首次上网日期，不代表论文的发表时间）