Variety of statistical for phase Ⅰ trials
The primary objective of experiments motivating this work is to estimate the unknown amount of treatment that has a probability of response equal to a fixed value Γ. 0 ≤Γ≤ 1. We further assume that it is desirable to center the distribution of treatment around the unknown quantile. This is accomplished by sequentially assigning treatment levels to subjects using up-and-down rules. Responses are to how stationary treatment distribution can be determined. The designs are shown to be robust with respect to the form of the response function.
Dose-response Phase Ⅰ trial Maximum tolerated dose (MTD)
Xueli Wang Xiuli Shi
College of Pilot, Beijing University of Technology, Beijing, 101101, P.R.China
国际会议
南京
英文
179-182
2010-07-29(万方平台首次上网日期,不代表论文的发表时间)