会议专题

Variety of statistical for phase Ⅰ trials

The primary objective of experiments motivating this work is to estimate the unknown amount of treatment that has a probability of response equal to a fixed value Γ. 0 ≤Γ≤ 1. We further assume that it is desirable to center the distribution of treatment around the unknown quantile. This is accomplished by sequentially assigning treatment levels to subjects using up-and-down rules. Responses are to how stationary treatment distribution can be determined. The designs are shown to be robust with respect to the form of the response function.

Dose-response Phase Ⅰ trial Maximum tolerated dose (MTD)

Xueli Wang Xiuli Shi

College of Pilot, Beijing University of Technology, Beijing, 101101, P.R.China

国际会议

2010 International Conference on Probability and Statistics of the International Institute for General Systems Studies(国际一般系统理论研究会中国概率统计学会第二届学术会议IIGSS-CPS2010)

南京

英文

179-182

2010-07-29(万方平台首次上网日期,不代表论文的发表时间)