How many negative feedbacks are needed in a genetic cascade? -A numerical study
In a typical genetic cascade, the positive feedbacks from one gene to another are necessary for the amplification of signals. However, continuous positive regulations would enlarge the noise such that the system will no longer stable. In this article, we have numerically studied the minimal number of negative feedbacks in a genetic cascade with 51 genes, and studied the effect of the distribution of the positions of negative regulations on the noise level. Our results showed that at least 1/4 regulations should be negative feedbacks, and no continuous 6 positive feedback could appear to avoid the uncontrollable random noise if the current noise is at the average level. Our conclusions may shed light on the design of a reasonable genetic cascade.
noise genetic cascade negativefeedback regulation system control
Zhiwei Wang Qingdai Liu Zhizhou Zhang
Key Laboratory of Food Nutrition and Safety.Ministry of Education, Tianjin University of Science and Bio-X Center for Marine Biotechnology.Lab of Molecular Nutrition and Food Safety.Harbin Institute of
国际会议
上海
英文
107-109
2010-06-22（万方平台首次上网日期，不代表论文的发表时间）