Triptolide can enhance the tumor suppression ability of VNP20009 by promoting bacteria colonization in tumor
Tumor therapy via tumor targeted salmonella has gained much attention for its clinic phase Ⅰ study in 2001. Unfortunately, no antitumor effects were observed, so additional studies are required to improve tumor localization. Here, we introduced a new method to magnify the salmonella tumor colonization by inhibiting the tumor angiogenesis. We found that treating C57B/L6 mice with salmonella VNP20009 and triptolide (PG490) led to a more significant decrease in tumor microvessel density and serum vascular endothelial growth factor (VEGF) level, which resulted in more hypoxia area in tumors. More salmonella VNP20009 could be detected in tumor under this condition, resulting in better tumor suppression effects. In this study, the tumor vessel suppression compounds such as triptolide could improve the salmonella tumor colonization and obtain significant tumor suppression effects, which may led to great promotion in clinic application with salmonella in tumor therapy.
salmonella VNP20009 triptolide tumor suppression tumor angiogenesis vessel clinic application
Jianxiang Chen Xiufeng Liu Yiting Qiao Zichun Hua
State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, College of Life Science,Nanjing University, Nanjing, 210093, China
国际会议
南京
英文
26-30
2010-05-12（万方平台首次上网日期，不代表论文的发表时间）