Correlation between evolution of HCV second envelope protein hypervariable region and titers of anti-F antibodies

摘要：

This study is to explore the relationship between HCV HVR1 quasispecies and detection of anti-HCV-F antibodies. HCV quasispecies from 44 HCV patients were detected by single-strand conformation polymorphism (SSCP) analysis of HVR1 in E2 region. Specific anti-HCV-F antibodies in sera of HCV patients were detected by indirect ELISA. The quasispecies bands of anti-HCV-F-positive and-negative were (5. 24±1. 98) and (2.24±1.06) (P<0.05), respectively. Thirty samples (68％) out of the 44 HCV patients were detected specific anti-HCV-F antibodies. In conclusion, the number of HCV quasispecies correlated with detection of anti-HCV-F antibodies and course of disease.

关键词： Hepatitis C virus (HCV) F protein hypervariable region (HVR) quasispecies

作者: Deng Xiao-zhao Kong Jing Chu Chun-li Zhang Yun Wang Zhong-chan Li Chun-lei Wei Juan

作者单位: Medical Institute of Nanjing Army, 293 Zhong-shan East Road, Nanjing, 210002, China Medical Institute of Nanjing Army, 293 Zhong-shan East Road, Nanjing, 210002, China,Huaiyin Institut

会议类型: 国际会议

会议名称: International Symposium on Pharmacogenomics and the Regulation of Drug Metabolism Enzymes and Genes(药物基因组学和药物代谢酶及基因调控国际研讨会)

会议地点: 南京

会议语种:英文

页码: 31-34

在线出版日期: 2010-05-12（万方平台首次上网日期，不代表论文的发表时间）