Proteomic analysis of triptolide on severe liver injury in mice

摘要：

Triptolide, a diterpene triepoxide, is one of the major components of most functional extracts of Tripterygium wilfordii Hook f and is known to have various biological effects, including immunosuppressive, anti-inflammatory and anti-tumor functions. We studied the inhibitory effect of triptolide on endotoxemia (ETM)-induced liver damage. Pretreatment with triptolide decreased the liver injury after LPS/D-GalN injection. We utilized comprehensive proteomics to identify alterations in liver protein expression during pretreatment with triptolide and pretreatment with N-acetylcysteine (NAC) after LPS/D-GalN injection, Forty four proteins were found to be related to oxidative stress, mitochondria, metabolism and signal transduction.

关键词： triptolide severe liver injury proteomics

作者: Yan Lu Weiwei Yang Ping ping Shen

作者单位: State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center (MARC)of Nanjing University, Nanjing University, Nanjing, 210093, China

会议类型: 国际会议

会议名称: International Symposium on Pharmacogenomics and the Regulation of Drug Metabolism Enzymes and Genes(药物基因组学和药物代谢酶及基因调控国际研讨会)

会议地点: 南京

会议语种:英文

页码: 51-53

在线出版日期: 2010-05-12（万方平台首次上网日期，不代表论文的发表时间）