Oridonin: A promising cell death-inducing anticancer drug from China
Oridonin, an ent-kaurene diterpenoid compound isolated from the leaves of Rabdosia rubescens (Hemsl. )Hara, has been used as an anti-inflammatory, antibacterial and anticancer agent in local folk medicine since ancient time. It has been widely recognized as a promising anticancer drug since 1970s. This review is concerned about the mechanisms underlying its anticancer activity. Oridonin induced tumor cell death through apoptosis, necrosis and autophagy without overt toxicity and side effects. Further endeavor to modify the structure of oridonin in order to improve its solubility and activity is worthwhile. Meanwhile, exploration on oridonin with other chemotherapeutics in cancer therapy is also a hot subject of the research.
Oridonin Tumor cell death anticancer
Zhang Wenjing Huang Qilai Hua Zi-Chun
Faculty of Traditional Chinese Medicine and Macau Institute for Applied Research in Medicine and Hea Faculty of Traditional Chinese Medicine and Macau Institute for Applied Research in Medicine and Hea
国际会议
南京
英文
62-64
2010-05-12（万方平台首次上网日期，不代表论文的发表时间）