Involvement of Na+ , K+-ATPase in lung epithelial inflammation

摘要：

Increasing evidence demonstrates that Na+, K+ -ATPase plays an important role in pulmonary inflammation, but the mechanism remains largely unknown. In this study, we used cardiotonic steroids as Na+, K+ -ATPase inhibitors to explore the possible involvement of Na+, K+ -ATPase in pulmonary epithelial inflammation. The results demonstrated that mice after ouabain inhalation developed cyclooxygenase-2-dependent acute lung inflammation. The in vitro experiments further confirmed that Na+, K+ -ATPase inhibitors significantly stimulated cyclooxygenase-2 expression in lung epithelial cells of human or murine origin, the process of which was participated by multiple ciselements and transacting factors.

关键词： Na+ K+-ATPase cardiotonic steroids acute lung inflammation cyclooxygenase-2 HuR

作者: Wei Chen Su Feng Dan Cao Zi-Chun Hua Wu Yin

作者单位: The State Key Laboratory of Pharmaceutical Biotechnology, College of life Sciences,Nanjing University, Nanjing, 210093, China

会议类型: 国际会议

会议名称: International Symposium on Pharmacogenomics and the Regulation of Drug Metabolism Enzymes and Genes(药物基因组学和药物代谢酶及基因调控国际研讨会)

会议地点: 南京

会议语种:英文

页码: 76-79

在线出版日期: 2010-05-12（万方平台首次上网日期，不代表论文的发表时间）