Discovery of novel small molecules that inhibit Human tongue squamous carcinoma cells (Tca8113)

摘要：

To identify novel inhibitors for human tongue squamous carcinoma, we screened the small Nutlins-like molecules for their efficacy against the cell line Tca8113 in vitro. Two novel cancer growth inhibitory compounds NL-11 and NL-19 were founded. They inhibited the proliferation of Tca8113 cells in a dose-dependent manner, and the effect mediated by inducing cell cycle arrest mainly in G2 phase. Flow cytometry demonstrated that the changes of the apoptotic cells exposed to increased concentrations of the NL-11 and NL-19 from early to late stage.

关键词： Tca8113 small molecule inhibitor apoptosis cell cycle arrest

作者: Yakun Ge Shanshan LI Weirong SHANG Yunpeng CHEN Yuanxin ZHANG Kun ZHENG Xu BAI Wei SHI

作者单位: Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education,Jilin University, Hospital of Stomatology, Jiamusi University, Jiamusi, 154002, China The Center for Combinatorial Chemistry and Drug Discovery, The College of Pharmacy,Jilin University, Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education,Jilin University,

会议类型: 国际会议

会议名称: International Symposium on Pharmacogenomics and the Regulation of Drug Metabolism Enzymes and Genes(药物基因组学和药物代谢酶及基因调控国际研讨会)

会议地点: 南京

会议语种:英文

页码: 152-157

在线出版日期: 2010-05-12（万方平台首次上网日期，不代表论文的发表时间）