Gender-related differential induction of peritoneal macrophage alternative in xenograft mice tumor models between male and female

摘要：

The present study was undertaken to investigate whether gender-related differential induction of peritoneal macrophage alternative activation is involved in the gender dimorphism of tumor growth observed in the xenograft tumor mice models. 106 murine liver tumor cell line Heps suspended in 200μL RPMI1640 medium were subcutaneously injected into the right flank of ICR mices in each group (n = 6). Tumors in male groups are larger than the ones in female group. Peritoneal macrophage displays alternative activation with high arginase activity in Heps tumor-bearing mice. Mannose receptor(CD206) expression is higher in peritoneal macrophage in male group than that of in female group. These studies might provide explanations for gender dimorphism of tumor growth and provide research data for clinical tumor therapy.

关键词： macrophage alternative activation xenograft tumor model gender dimorphism

作者: Wu Yuanyuan Yang Weiwei Shen Pingping

作者单位: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sicence,Nanjing University, Nanjing, 210093, China

会议类型: 国际会议

会议名称: International Symposium on Pharmacogenomics and the Regulation of Drug Metabolism Enzymes and Genes(药物基因组学和药物代谢酶及基因调控国际研讨会)

会议地点: 南京

会议语种:英文

页码: 168-171

在线出版日期: 2010-05-12（万方平台首次上网日期，不代表论文的发表时间）