Gender-specific Effect of Deficient Abcg4 on Lipogenesis in Mouse Brain

摘要：

The mRNA levels of the genes for lipid lipogenesis as well as others were quantified in the brains of Abcg4 knockout and wild-type mice using quantitative RT-PCR. The results showed that different genes of lipid metabolism were activated in the brains of Abcg4-/-male and female mice, when compared to those of wildtype control. It was shown that Abcg4 is a sex-regulated gene with the function of regulating fatty acid and/or cholesterol synthesis in the brain.

关键词： ATP-binding cassette transporter (ABC) abcg4 cholesterol lipogenesis gene knockout mouse quantitative PCR brain

作者: Jinmei Wu ShaileshB.Patel

作者单位: College of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, 212018, P.R.China Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA

会议类型: 国际会议

会议名称: International Symposium on Pharmacogenomics and the Regulation of Drug Metabolism Enzymes and Genes(药物基因组学和药物代谢酶及基因调控国际研讨会)

会议地点: 南京

会议语种:英文

页码: 174-178

在线出版日期: 2010-05-12（万方平台首次上网日期，不代表论文的发表时间）