Preparation and characterization of Poly-(N, N-dimethyl amino) ethyl methacrylate/Poly (vinyl alcohol) Semi-Interpenetrating (Semi-IPN) Hydrogel
Object to prepare thermo-sensitive and pH-sensitive intelligent hydrogels. The phase transition temperature of different components hydrogels were studied by using UV-VIS spectrophotometer at λ=550nm. Further more, swelling ratios were investigated at different temperature and pH value. This research would provide research foundation for drug delivery system. INTRODUCTION Controlled drug delivery systems via targeted drug delivery of a predetermined dose over a sustained period have been used to overcome the shortcomings of conventional dosage forms 1. This is because the controlled drug delivery system can provide sustained therapeutic level of drug concentration without toxicity. Drug delivery technology also provides convenience for patients. It would be more beneficial and ideal if a device that would respond to physiopathological signals from an underling disease could deliver the drug. The correct amount of drug would be released upon the stimulation of such a physiopathological signal.
Hui Li Guo-li Gong Jing Zhang Baoyuan He Shuntian Jia Chaohua Xue
Key Laboratory of Aids Chemistry and Technology for Light Chemical Industry, Ministry of Education, College of Life Science and Engineering, Shaanxi University of Science and Technology,Xian 710021
国际会议
上海
英文
842-845
2009-05-27（万方平台首次上网日期，不代表论文的发表时间）