Synthesis and antimicrobial activity of chitosan biguanidine hydrochloride
Chitosan biguanidine hydrochloride (CGH) has been synthesized by the guanidineylation reaction of chitosan with dicyandiamide. Its synthetic mechanism and conditions were studied. The structures of CGH were characterized by UV, FT-IR. The antimicrobial activities of CGH were measured by means of the minimal inhibition concentration (MIC). The substitution degrees of guanidinylated chitosan were confirmed by elemental analysis. In vitro antimicrobial activity of guanidinylated chitosans with different substitution degrees were evaluated against staphylococcus aureus, bacillus subtilis, escherichia coli and pseudomonas aeruginosa. The results show that CGH are effective of bacteriostasis, compared with chitosan, guanidinylated chitosan had much better antibacterial activity. The antibacterial activity of chitosan biguanidine hydrochloride derivative enhanced with increasing substitution degrees of guanidinylated chitosan.
chitosan biguanidine hydrochloride synthesis antimicrobial mechanism
ZHAO Xue QIAO ZHEN-zhen HE JIN-xin ZHAN Yi-zhen
College of Chemistry & Chemical Engineering Donghua University, Shanghai 201620,China Saintyear Holding Group Company, Hangzhou 311221, China
国际会议
上海
英文
906-911
2009-05-27（万方平台首次上网日期，不代表论文的发表时间）