In vitro mineralization of surface-modified electrospun polycaprolactone scaffolds in simulated body fluid
The aim of this study is to develop a facile and efficient process to provide electrospun polycaprolac-tone(PCL) scaffold with a bone-like apatite coating while maintaining its fibrous and porous structure. First, PCL scaffolds with uniform fibrous structure were fabricated by electrospinning. Second, NaOH was used to activate the surface of the scaffold. Before mineralization, a Ca-P treatment was utilized to deposite some apatite nuclei onto the surface. Then, the treated PCL scaffolds were immersed in SBF for varying periods. PCL fibers were found to mineralize after immersion in SBF for 6h. The coating of apatite was determined to have some similarities with that from natural bone. A preliminary study was conducted on PCL scaffolds and mineralized PCL scaffolds. The results proved that the apatite coating on the scaffolds support fibroblasts growth and proliferation. As the mineralized electrospun scaffold has a similar structure as the natural bone, it is expected to have some potential in bone tissue engineering.
electrospinning polycaprolactone scaffolds apatite
Lingli Li Guang Li Jiangyue Zhou Jianming Jiang
College of Material Science and Engineering, Donghua University, Shanghai, 201620
国际会议
上海
英文
1367-1369
2009-05-27（万方平台首次上网日期，不代表论文的发表时间）