A Cultivation Device for the Study on Mechanobiology of Cartilage in Vitro
(0) There is a large number whose cartilage are damaged due to injury, osteoarthritis and tumor every year. In general, the regeneration capacity of articular cartilage injury difficult to self-repair is considered to be limited. At present, many new technologies and methods have been used for clinical treatment, but it only can relieve the pain of the patients. Human knee joint has two main movement patterns: one for the rolling; another for the sliding. Rolling, as a typical representative of the articular cartilage, is very similar to the mechanical environment in vivo. Accordingly, we first proposed and developed this rolling depression loading device with perfusion system for the mechanobiology researching on in vitro articular cartilage, which includes rolling control system, compression adjusting system and circulating perfusion system. The roll controlling system is achieved by roller rolling back and forth through stepper motor driving screw rod. The compressive syitem could produce uniform, controlled compressions by relatively sliding of two wedge blocks. The circulating perfusion system is mainly finished by controlling the peristaltic pump. It can provide an environment which is closer to the normal physiological condition of articular cartilage. Rolling depression loading is useful to clarify the pathogenesis of osteoarthritis and apply biomechanical factors to prevent and treat osteoarthritis and repair cartilage. This device is small enough to work in the general culture box, and we will test it with biological experiment in future.
rolling depression loading mechanobiology vitro cartilage
Junxia Gao Chunqiu Zhang Haiying Liu Lilan Gao Minglin Sun Xin Dong
School of Mechanical Engineering, Tianjin University of Technology Tianjin Key Laboratory for Contro Department of Orthopaedics, Affiliated Hospital of Chinese Peoples Armed Police Force, Tianjin 3001 Department of mechanics, College of Mechanical Science and Engineering, Jilin University, Changchun
国际会议
成都
英文
15-17
2011-01-14（万方平台首次上网日期，不代表论文的发表时间）