Expression and Clinicopathology of Heat Shock Protein 72 and Glycoprotein 96 in Human Esophageal Squamous Cell Carcinomas
Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and expression of HSP72 and gp96 in human esophageal squamous cell carcinoma. The expression of HSP72 and gp96 was studied in 120 human esophageal squamous cell carcinomas with or without metastasis as well as in mucous membrane adjacent to cancers by way of immunohistochemistry. HSP72 immunoreactivities were detected in 112 of 120 primary tumors (93.3％) and in 30 of 120 mucous membranes adjacent to cancers (25.0％). Gp96 detected in esophageal squamous cell carcinoma and in mucous membrane adjacent to cancer was 85.0％ and 20.0％ respectively. Both HSP72 and gp96 mainly stained in cytoplasm. HSP72 and gp96 expression in esophageal squamous cell carcinomas with metastasis was significantly higher than those with non-metastasis (P < 0.05). The results indicate that there exists a significant correlation between the expression of HSP72 and gp96 and the progression of esophageal squamous cell carcinomas. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node and remote metastasis. The high-level expression of HSP72 and gp96 may be used as diagnostic or prognostic markers for esophageal squamous cell carcinoma.
heat shock protein 72(HSP72) glycoprotein 96(gp96) esophageal squamous cell carcinoma clinicopathology prognosis
Xiaoping Wang Huanping Lin Qiaoxia Wang
Lab of Molecular Pathology Shaanxi University of Chinese Medicine Xianyang 712046 China Department of Infectious Diseases Xian Jiaotong University Affiliated Xian Central Hospital Xian
国际会议
成都
英文
98-101
2011-01-14（万方平台首次上网日期，不代表论文的发表时间）