Effect of highly active antiretroviral therapy (HAART) on lipid abnormalities in HIV-infected patients
(0) Dyslipidemia is a common metabolic complication among HIV-infected patients who receive protease inhibitor (PI)-based antiretroviral therapy (ART). The aim of this study is to assess the prevalence of lipid abnormalities and related factors among HIV-infected patients. A cross-sectional analytic study of the lipid profiles of 170 adult HIV-infected patients receiving PI-containing HAART who attended the HIVclinic, Vishwakarma Hospital, Karunapuram, Warangal district between July and December 2009 was conducted. Studied subjects had a median age of 40 years with a median duration of taking PIs of 22.1 months. The mean serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), and triglyceride (TG) levels were 259.7, 43.7, 135.2, and 506.8 mg/dl, respectively, and the mean TC.HDLc ratio - 6.4. Seventy-five subjects (44.1％) were taking lipidlowering drugs. Only 54 subjects (31.8％) had baseline serum lipid profiles tested before beginning PI. There was statistically significant association between group of PI with serum TC and TG. Subjects taking double boosted and single boosted PI had significantly higher serum TC and TG levels than unboosted PL Males had significantly higher serum TG levels, while females had significantly higher serum HDL-c levels. Age was significantly associated with serum TC, LDL-c levels, and TC:HDL-c ratios. Serum TC and LDL-c levels were also significantly higher in subjects taking efavirenz.
Dyslipidemia HAART PI lipid profiles
Estari Mamidala
Department of Zoology, Kakatiya University, Warangal. Andhra Pradesh, India
国际会议
成都
英文
234-237
2011-01-14（万方平台首次上网日期，不代表论文的发表时间）