MULTISCALE MODELLING OF BIOLOGICAL SYSTEMS
Biological structures like soft tissues and cells are anisotropic non-homogenous materials having their properties dependent on the external stimuli as well as physiological activities like growth, diseases,damage etc. A deeper insight into the behavior of these structures is required to understand the characteristic response of the tissues under normal and pathological conditions. The mechanical properties of these tissue structures are closely related to the internal molecular structure and therefore a computational analysis procedure requires integration of physics occurring at different length and time scales. Involving all the processes into a single framework requires a multiscale-multiphysical model and it usually presents a high end mathematical and computational challenges. The development of computational models to study the behavior of cancer cells, and tumor tissues are presented in this paper. The constitutive models of soft tissues are based on a multiscale approach starting from the cellular level and eventually crossing over to the macroscopic scales of tissues. The applicability of the computational models to serve as diagnostic tools, for therapeutic interventions in gynecological situations is also discussed.
J.N.Reddy G.U.Unnikrishnan V.U.Unnikrishnan
Department of Mechanical Engineering Texas A&M University, College Station, TX 77843-3123 USA
国际会议
广州
英文
26-32
2010-12-17（万方平台首次上网日期，不代表论文的发表时间）