Bioinformatics Analysis and Characteristics of VP23 Encoded by the Newly Identified UL18 Gene of Duck Enteritis Virus
In this study, the predicted information about structures and functions of VP23 encoded by the newly identified DEV UL18 gene through bioinformatics softwares and tools. The DEV UL18 was predicted to encode a polypeptide with 322 amino acids, termed VP23, with a putative molecular mass of 35.250 kDa and a predicted isoelectric point (PI) of 8.37, no signal peptide and transmembrane domain in the polypeptide. The prediction of subcellular localization showed that the DEV-VP23 located at endoplasmic reticulum with 33.3％, mitochondrial with 22.2％, extracellular, including cell wall with 11.1％, vesicles of secretory system with 11.1％, Golgi with 11.1％, and plasma membrane with 11.1％. The acid sequence of analysis showed that the potential antigenic epitopes are situated in 45-47, 53-60, 102105, 173-180, 185-189, 260-265, 267-271, and 292-299 amino acids. All the consequences inevitably provide some insights for further research about the DEV-VP23 and also provide a fundament for further study on the the new type clinical diagnosis of DEV and can be used for the development of new DEV vaccine.
Bioinformatics VP23 Structure Function Duck Enteritis Virus
Xiwen Chen Anchun Cheng Mingshu Wang Jun Xiang Anchun Cheng Mingshu Wang Xiwen Chen
Avian Disease Research Center College of Veterinary Medicine of Sichuan Agricultural University Yaa Key Laboratory of Animal Disease and Human Health of Sichuan Province College of Veterinary Medicine Institute of Applied Animal Technology, Key Laboratory for Molecular Biology and Biopharmaceuticals
国际会议
2010 International Conference on Signal and Information Processing(2010年IEEE信号与信息处理国际会议 ICSIP2010)
长沙
英文
255-260
2010-12-14（万方平台首次上网日期，不代表论文的发表时间）