Genomic investigation of invasion associated genes expression in Salmonella enterica serovar Typhi at enteric environmental stresses
Salmonella enterica serovar Typhi (S. Typhi) is a gram-negative human enteroinvasive pathogen and an important model prokaryote also. Intestinal invasion by 5. Typhi is associated with many pathogen-specific factors, including Type Ⅲ secretion systems, secretion of invasion related proteins, flagella and motility, and reducing of Vi polysaccharide. During the infection procedure, Salmonella should be suffer from many kinds of severe environmental stress, such as gastric acid stress, hyperosmotic stress, bile acids stress and oxidative stress. Bacteria must regulate numerous genes expression though the complex regulatory network to adapt different stresses. DNA microarray technique has been widely used in analysis of bacterial expression profiles, which is beneficial to clarify the network of gene expression regulation. By a genomic oligo DNA microarray, we previously found the gene expression kinetics of 5. Typhi during Hyperosmotic Stress in vitro.
Xiumei Sheng Haifang Zhang Hong Du Xinmin Xie Zhe Luo Min Wang Bin Ni Shungao Xu Xinxiang Huang
Department of Biochemistry and Molecular Biology, Jiangsu University School of Medical Technology, Zhenjiang, Jiangsu 212013, PR China
国际会议
International Symposium on Bacterial Genomics,Evolution and Pathogenesis(病原菌基因组进化与致病机制国际研讨会)
江苏镇江
英文
40-41
2010-11-30（万方平台首次上网日期，不代表论文的发表时间）