Comparative genomics of Yersinia pestis isolates and vaccine strain EV76 by whole genome microarray

摘要：

Background Yersinia pestis is a gram negative bacterial pathogen that causes bubonic and pneumonic plagues. Three pandemics have been recorded in the human history, and the modern plague is thought to origin from Chinese Yunnan province. Yersinia pestis origins from a clone of the enteropthogen Yersinia pseudotuberculosis 1500-20000 years ago, and they share 80％ homogeneous genes including the 102Kb pgm loci. However they exhibited a different pathogenic phenotype and virulence. Therefore the 102Kb pgm pathogenicity island is not the sole possession of Yersinia pestis, it can be concluded that missing this island is not the fatal factor for virulence attenuation of EV76.

作者: Peng Wang Jianzhong Zhang Yuanhai You Yanhua Wang Maojun Zhang Zhizhong Song Rong Hai Dongzheng Yu Haibin Wang XingQi Dong

作者单位: Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Pr Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Pre Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Pr Yunnan Institute for Endemic Disease Control and Prevention, Dali, China Yunnan Institute for Endemic Disease Control and Prevention,Dali, China

会议类型: 国际会议

会议名称: International Symposium on Bacterial Genomics,Evolution and Pathogenesis(病原菌基因组进化与致病机制国际研讨会)

会议地点: 江苏镇江

会议语种:英文

页码: 63-65

在线出版日期: 2010-11-30（万方平台首次上网日期，不代表论文的发表时间）