Production of single chain antibody against anthrax toxin in Escherichia coli

摘要：

Introduction Because of high and specific affinities for various biomolecules, stability, and easy production in bacterial hosts such as Escherichia coli, many recombinant antibody fragments such as single chain Fv (scFv), antibody-binding fragment (Fab) etc have been developed and applied to medicine and biotechnology. As one of antibody fragments format, single chain antibody (scAb) in which human Constant kappa domain is connected to carboxy terminus of a single chain Fv (scFv) (figure 1) has a great potential for specific research and clinical trials, because of its small size, improved stability and enhanced pharmacokinetic properties compared to scFv.

作者: KI JUN Jeong George Georgiou

作者单位: Dept. Chemical and Biomolecular Engineering,KAIST,Korea,Univ. of Texas at Austin,USA Dept Chemical Engineering,Univ. of Texas at Austin,USA

会议类型: 国际会议

会议名称: The Eleventh China-Japan-Korea Joint Symposium on Enzyme Engineering(第十一届中日韩酶工程学术研讨会)

会议地点: 成都

会议语种:英文

页码: 184-185

在线出版日期: 2010-11-05（万方平台首次上网日期，不代表论文的发表时间）