On the electro-mechanical coupling behavior of cell membrane:nonlinear shell model

摘要：

INTRODUCTION Cell electroporation and electropermeabilization are routinely used in cell biology for protein, drug, RNA or DNA transfer 1. Its clinical applications are under development for targeted drug delivery and gene therapy. The biological cell membrane can be treated as a nano-scale flexibly bi-layered structure. Although the internal structure of cell membrane is very complicated, it is simplified as a thin dielectric insulator layer in present study. Hereby a spherical cell membrane with zero resting potential exists within an extracellular medium of infinite extent and it is also exposed to a uniform applied electric field (see Fig.1).

关键词： Dielectric cell membrane electromechanical coupling nonlinear thin shell thickness variation

作者: Lianhua Ma Qingsheng Yang Bernard F. Rolfe Chunhui Yang

作者单位: Department of Engineering Mechanics, Beijing University of Technology, Beijing 100124,China Department of Engineering Mechanics, Beijing University of Technology,Beijing 100124,China School of Engineering, Deakin University, Waurn Ponds, VIC 3217, Australia

会议类型: 国际会议

会议名称: The 2nd International Conference on Nanomechanics & Nanocomposites(第二届国际纳米力学与纳米复合材料会议)

会议地点: 北京

会议语种:英文

页码: 271-274

在线出版日期: 2010-10-10（万方平台首次上网日期，不代表论文的发表时间）