Immobilization of biomolecules on the surface of CdS and CdTe and their biomedical application
INTRODUCTION Semiconductor nanocrystals, known as quantum dots (Q-dots), have got enormous interest in recent time due to their unusual optical and electronic properties 1. Compared with traditional organic fluorophores, Q-dots show considerable advantages including size-tunable emission, narrow spectral line widths, high luminescence, continuous absorption profile and excellent stability against photobleaching 2. But Cytotoxicity is a severe problem of cadmium sulfide nanoparticles for use in biological systems 3. So appropriate coating is necessary to use Q-dots in biological system. In the current study, mercaptoacetic acid-coated cadmium sulfide nanoparticles (CSNPs) and PEG-coated cadmium telluride nanoparticles (CTNPs) were synthesized in an aqueous medium by the arrested precipitation method at room temperature. Then, the surface of the CSNPs and CTNPs were modified with biomolecules to enhance the biocompatibility and fluorescence intensity. Finally, peptide ligand was introduced to the surface of the nanoparticles to realize receptor targeting and molecular imaging. To evaluate the cytotoxicity of surface modified CSNPs and CTNPs, human fibroblast cells were cultured in the presence of nanoparticles.
Q-dots surface modification peptide
Moon-Jeong Choi K. M. Kamruzzaman Selim Haiqing Guo Inn-Kyu Kang
Department of Medical and Biological engineering, Kyungpook National University,Daegu 702-701, Repub Department of Polymer Science and Engineering, Kyungpook National University, Daegu 702-701, Republi School of Molecular Engineering and Chemistry, Peking University, Beijing, China Department of Medical and Biological engineering, Kyungpook National University, Daegu 702-701, Repu
国际会议
The 2nd International Conference on Nanomechanics & Nanocomposites(第二届国际纳米力学与纳米复合材料会议)
北京
英文
364-365
2010-10-10（万方平台首次上网日期，不代表论文的发表时间）