A First Look at the Co-evolution Modules in Drosophila Genome
The prediction of protein-protein interaction (PPI) has become a major issue of bioinformatics, and many methodologies were developed to accurately predict PPI using sequences data, gene expression data et al. Pazos and Valencia proposed a PPI prediction method using protein evolution information called Mirror Tree Method (MT Method) in 2001. It assumed that PPI is a key determinant of molecular function thus can constrain the genetic mutation of both interacting proteins. It calculated and compared the co-evolution index of interacting and noninteracting protein pairs by construction of phylogenetic trees and calculation of distance matrices in different organisms. The co-evolution index was defined as the Pearsons correlation of two distance matrixes of two proteins. Since it has been well known that proteins work together to form functional modules and pathways in vivo, it is reasonable to raise the assumption that the coevolution phenomenon may also happen in modules and pathways.
Yiming Lu Wubin Qu YangZhou Chenggang Zhang
Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics,Beijing 100850, China
国际会议
杭州
英文
11-13
2010-10-01（万方平台首次上网日期，不代表论文的发表时间）