Effects of pH and temperature on the structural and thermodynamic character of α-syn12 peptide in aqueous solution
Human a-synuclein protein, a presynaptic protein of 140 amino acid residues, is the major component of Lewy bodies (LBs) deposited in the brains of patients with Parkinsons disease, and it usually has extensive intrinsically disordered (ID) regions (IDRs). Typical of Parkinsons disease is the presence of a-synuclein aggregates in the form of Pstructure that can be soluble or insoluble. Hu et al had reported that the N-terminal 12 residues peptide of a-synuclein (a-syn 12) effectively competed with the N-terminal 65 residues peptide of a-synuclein for binding to the coiled-coil domain of Synphilin-1.
Zanxia Cao Lei Liu Jihua Wang
Key Lab of Biophysics in Universities of Shandong (Dezhou University), Dezhou, China, 253023 Departm Department of Computer Science and Technology, Dezhou University, Dezhou 253023, China
国际会议
杭州
英文
82-83
2010-10-01（万方平台首次上网日期，不代表论文的发表时间）