Genome-scale metabolic network analysis of the opportunistic pathogen Burkholderia cenocepacia J2315
Burkholderia cenocepacia is an emerging gramnegative opportunistic pathogen that commonly infects patients with cystic fibrosis (CF) and immunocompromised individuals. This bacterium is notorious for its high levels of antibiotic resistance, yet the mechanisms of host infection and drug resistance remain mostly unknown. The genome of B. cenocepacia J2315 has been sequenced and recently annotated. The 8.06-Mb genome is equipped with versatile metabolic capabilities and multi virulence traits that allow it to survive under a variety of conditions and invade impaired host cells. A systematically understanding of the metabolism of B.
Genome-scale metabolic network reconstruction B.cenocepacia flux balance analysis
Kechi Fang Hansheng Zhao Changyue Sun Jing Wang
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
国际会议
杭州
英文
93-94
2010-10-01（万方平台首次上网日期，不代表论文的发表时间）