Genome-wide identification of novel homologous microRNAs in the marmoset genome by comparative genomics method
Background MicroRNAs (miRNAs) are a vital class of regulated RNAs. They regulate gene expressions by base pairing to target mRNAs for translation repression or mRNA degradation. Although deep sequencing is a very effective method to discover small non-coding RNA on a large scale, but it is still an expensive and labour intensive to most laboratories and it can only identify miRNAs expressed in a given condition. While the sequencing technology now allow faster sequencing at a lower cost than ever before, more and more genome data of organisms will be produced. Thus using these genomic data, we can predict novel homologs of miRNAs depend on conservation of hairpins in closely related species by comparative genomic methods.
Zhidong Yuan Xiao Sun
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering,Southeast University, Nanjing 210096, China
国际会议
杭州
英文
98-100
2010-10-01（万方平台首次上网日期，不代表论文的发表时间）