Molecular determinants affecting the short-lived protein in mammalian cells

摘要：

Motivation: Protein turnover metabolism plays an important role in cell cycle progression, signal transduction, and differentiation. Those proteins with short half-life are involved in various regulatory processes. To better understand the regulation of cell process, it is also important to understand protein breakdown in addition to protein synthesis. Until now, most of proteins half-life is unknown for us due to the difficulties of traditional experimental methods in measuring proteins half-life in mammalian cells. To investigate the molecular determinants affecting the protein half-life, a computational method was proposed in this work to recognize those short-lived proteins based on sequence-derived features in mammalian cell.

作者: Hao Jia Xuejiang Guo Xiaofeng Song Ping Han Xiaobai Zhang Jiahao Sha

作者单位: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics,Nanjing 210 Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing The First Hospital affiliated to Nanjing Medical University,Nanjing 210029 China

会议类型: 国际会议

会议名称: 第四届全国生物信息学与系统生物学学术大会

会议地点: 杭州

会议语种:英文

页码: 134-137

在线出版日期: 2010-10-01（万方平台首次上网日期，不代表论文的发表时间）