Strategies and Challenges of Genome-Wide Association Studies
Genome-wide association (GWA) studies use dense maps of single nucleotide polymorphisms (SNPs) that cover the human genome to pinpoint or characterize chromosome regions or loci susceptible to disease status or phenotypic trait. With the completion of Human Genome Project and the International HapMap Project, as well as the booming development of high throughput genotyping techniques, GWA studies have become the major strategies in deciphering the geneticmechanism of human complex diseases. Currently, of the most commonly investigated genetic markers, SNPs rank the top and there are millions of SNPs in human genome. Accruing evidence indicates that the detection of 300 to 500 thousands of SNPs will cover most of the genetic variation in the genome with enough statistical power.
Mingliang Gu Wenquan Niu
Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,Chaoyang Distr State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Me
国际会议
杭州
英文
201-203
2010-10-01（万方平台首次上网日期，不代表论文的发表时间）