10-bp periodicity as an indicator of nucleosome position

摘要：

In this study, fast Fourier transformation (FFT) was used to directly detect 10-bp periodicity of AA-TTAT/GC in the human genome. We demonstrated that the 10-bp periodicity signal decreases near transcription start sites (TSSs), which correspond to nucleosome free regions (NFR). Moreover, the 10-bp periodicity signal in promoters negatively correlates with gene expression levels. The results indicate that 10-bp periodicity is closely associated with nucleosome positioning and can be an indicator of the presence of nucleosomes.

关键词： 10-bp periodicity nucleosomes gene expression

作者: Hongde Liu Huan Huang Xueye Duan Xiao Sun

作者单位: State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China

会议类型: 国际会议

会议名称: 第四届全国生物信息学与系统生物学学术大会

会议地点: 杭州

会议语种:英文

页码: 208-210

在线出版日期: 2010-10-01（万方平台首次上网日期，不代表论文的发表时间）