EFFECT OF TOTAL SAPONIN OF PANAX GINSENG (RENSHEN) AND ITS DERIVATIVE ON MOUSE IMMUNOCYTES
This study was designed to investigate the effect of Total Saponin of Panax Ginseng (TSPG) and its derivative on related immunocytes in vitro. The cytotoxicity of TSPG or derivative against splenocytes in vitro, and proliferation of T and B lymphocytes induced by ConA or LPS were determined by MTT assay. NK cell competence was determined using lactate dehydrogenase approach. The data showed that the cytotoxicity of TSPG against mouse splenocytes increased when TSPG concentration increased, but the cytotoxicity of TSPG derivative against mouse splenocytes decreased when the derivative concentration increased. Proliferation of T and B lymphocytes were significantly promoted by the derivative plus ConA or LPS. Thus, we concluded that the cytotoxicity of the derivative was weak against mouse immunocytes, and the derivative can significantly improve related immunocyte competence.
Total Saponin of Panax Ginseng (TSPG) Derivative Immunocyte
Zhiting Guo Xubin Wei Jianping Liang Xiaoqin Luo Wenzhu Guo Xuehong Wang Yu Liu Baocheng Hao
国际会议
兰州
英文
35-38
2010-09-13（万方平台首次上网日期，不代表论文的发表时间）