STUDIES ON ANTIMICROBIAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP OF DITERPENE QUINONE COMPOUND FROM SAL VIA PRZEWALSKII MAXIM WITH HANSCH AND FREE-WILSON

摘要：

The antimicrobial quantitative structure-activity relationship (QSAR) of 23 diterpene quinones against Staphylococcus aureus and their derivatives related activity was studied with Hansch combined with FreeWilson. The QSAR equation was established using multiple regression statistics. The results show that the dihydrofuran ring and the O-quinone structure is characteristic group or effective parts anti- Staphylococcus aureus, there are some correlations between lipid-water partition coefficient and the antibacterial activity.

关键词： antimicrobial QSAR diterpene quinine Salvia Przewalskii Maxim

作者: Yongjiang Luo Yanbing Shi Ying Cui Zhenying Hu Ruihua Xin Jifang Zheng

会议类型: 国际会议

会议名称: The ist International Conference on Traditional Chinese Veterinary Medicine,The 12th Chi Institute Annual Conference(首届中兽医药学国际学术研讨会)

会议地点: 兰州

会议语种:英文

页码: 67-70

在线出版日期: 2010-09-13（万方平台首次上网日期，不代表论文的发表时间）