Specifically Progressive Deficits of Default Mode Network Inamnestic Type Mild Cognitive Cimpairment: a Follow-up Study
Objective. Mild cognitive impairment (MCI) is believed to be an intermediate state between normal aging and dementia. Amnestic MCI (aMCI) is assumed if the impairment involves memory domain that is proposed as a risk factor for Alzheimers disease (AD), whereas non-aMCI concerned to non-memory deficits are often conceptualized as the prodromal phase for other causes of dementia. Early detection of disease processes of aMCI which presage the development of AD and a better understanding of the functional markers would be of benefit in terms of determining intervention and management strategy and likely prognosis. Images of amyloid deposition taken at the earliest stages of AD showed a distribution that is remarkably similar to the anatomy of default mode network (DMN), and increased amyloid deposition is associated with aberrant DMN activity and reduced functional connectivity within the DMN in AD patients, implying that AD pathology forms may be preferentially throughout the DMN. However, longitudinal studies of this network have not been reported in aMCI and identifying markers of DMN for aMCI expected to convert to AD would be of considerable interest.
Zhijun Zhang
Department of Neurology, Affiliated Zhongda Hospital and Institute of Neuropsychiatry of Southeast University, Nanjing, China
国际会议
The 7th International Conference on Cognitive Science(第七届国际认知科学大会 ICCS 2010)
北京
英文
145-146
2010-08-01（万方平台首次上网日期，不代表论文的发表时间）