Electrospinning and Post-spin Treatment of Regenerated Silk Fibroin Nanofibers

摘要：

In this stud.y, we had successfully fabricated nanofibers with regenerated silk fibroin (RSF, from Bombyx mori) aqueous solution via electrospinning. As-spun fibers were treated with 75％ ethanol vapor and pure methanol vapor, respectively. After immersing the membranes in phosphate buffered saline (PBS) for 4 days, the morphology of nanofibrous membranes treated with 75％ ethanol vapor had no obvious change; however, the methanol vapor treated nanofibers had swelled slightly as shown by SEM. The C13-NMR and WAXD analysis demonstrated that both the ethanol and methanol treatments rendered the structure of RSF nanofibrous membranes transform from silk Ⅰ form (which is dominated by random coil/αhelical conformation) to silk Ⅱ (in which β-sheet conformation prevails). As a green processing, 75％ ethanol vapor treatment not only improves the water-resistant property of SF nanofibrous membranes, but also is a beneficial sterilization way for drug loaded SF nanofibers.

关键词： electrospinning nanofiber silk fibroin post-spin treatment

作者: FAN Lin-peng ZHANG Kui-hua SHENG Xiao-yue WU Chun-chen LI Jun MO Xiu-mei WANG Hong-sheng

作者单位: Key Laboratory of Textile Science & Technology, Ministry of Education, Donghu-a University, Shanghai Key Laboratory of Textile Science & Technology, Ministry of Education, Donghu-a University, Shanghai Institute of Biologic Science and Biotechnology, Donghua University, Shanghai, P. R. China 201620

会议类型: 国际会议

会议名称: 2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)

会议地点: 上海

会议语种:英文

页码: 96-100

在线出版日期: 2010-05-28（万方平台首次上网日期，不代表论文的发表时间）