In Vitro Mineralization of Poly(3-hydroxybutyrate-co-3 hydroxyvalerate) Blended with Pearl Powders by Incubation in Simulated Body Fluids
In this study, the promising biodegradable poly(3hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) films blended with pearl powders were used as a matrix to prepare a composite containing hydroxylapatite(HA). Firstly, PHBV with incorporation of pearl powders were casted into films from solutions. And then these films were treated by NaOH to develop some active groups to initiate the growth of HA. Finally, the NaOH treated films were incubated in a simulated body fluid(1.5SBF) to prepare HA/PHBV/Pearl composites. It was found that the bone-like apatite formability of PHBV/Pearl films is enhanced by both blending pearl powders and alkali treatment. The apatite growed in the surface of films is more similar in morphology and composition to that of natural bone. Besides, the mechanical property of PHBV films is enhanced owing to the presence of pearl powders, and the hydrophilicity of PHBV is also improved. The surface chemistry and physical characteristics of the composites were examined by using EDS, FT-IR-ATR and the contact angle tester. The apatite was characterized by using SEM, TF-XRD, TGA. The results indicated that blending pearl powders in PHBV is an effective and convenient method to improve a series of properties of PHBV films, and NaOH treatment of PHBV/Pearl films is able to in further accelerate bone-like apatite formation via biomimetic method.
NaOH treatment pearl powder PHBV biomineralization
MENG Xing-hua LI Guang
College of Materials Science and Engineering, Donghua University, Shanghai, 201620, P. R. China
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
124-129
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）