Potential of a Benzalkonium Chloride-containing Bacterial Cellulose Dry Film on Acute Traumas
A kind of antibacterial BC dry film was developed as the functional wound dressing for acute traumas treatment. To achieve this, the freeze-dried go film was immersed in the benzalkonium chloride solution, a sort of broad-spectrum antimicrobial agent, which belongs to cationic surfactant, followed by another freeze-drying step. Some physical and antimicrobial properties of the prepared BC films were investigated and the results showed that the drug-loading capacity of the BC dry film was about 0. 11 mg/cm2 when prepared in 0. 102％ benzalkonium chloride solution. High water adsorption ability, an important quality for wound dressings was also achieved with a swelling ratio of 26.2. With respect to the antimicrobial effect, a stable and prolonged antimicrobial activity for at least 24 h was obtained especially against Staphylococcus aureus and Bacillus subtilis, which were general Gram-positive bacteria that found on the contaminated wound.
antimicrobial wound dressing bacterial cellulose acute traumas benzalkonium chloride
WEI Bin YANG Guang HONG Feng
Group of Microbiological Engineering and Industrial Biotechnology, College of Chemistry, Chemical En Group of Microbiological Engineering and Industrial Biotechnology, College of Chemistry, Chemical En
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
141-146
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）