Synthesis and Release Behavior of Polymeric Naproxen-saccharide Conjugate with Glucose Pendant
Recent years, the study of controlled release of drug from macromolecular has attracted many researchers from all over the world. In the present work, naproxen and glucose was converted to polymerizable derivatives that were subsequently polymerized to afford the macromolecular combination. Polymeric prodrug was synthesized using an efficient chemical enzyme combined method. Copolymers combined the individual properties of saccharide and macromolecular. The structure of polymeric prodrug was confirmed by FTIR, NMR and GPC. The molecular weight reached 2. 743 × 104. Furthermore, the in vitro release behaviors of naproxen and the polymeric prodrug were investigated in pH 7.4 buffer solution at 37℃. It was suggested that parent drug was fast released and the cumulative release amount was almost 100％ after 3.5 h in cellophane membrane bags, while only about 8％ of naproxen was released from polymeric prodrug in the same time. The continuous release investigation showed that the cumulative drug release reached 68％ after 10 days. It obvious demonstrated that the polymeric drugsaccharide conjugate had a better effect of prolonged release. The release behavior in different pH solution indicated that the pH of the environment is a very important factor influencing the degradation kinetics.
naproxen polymeric prodrug sustained-release glucose drug delivery system
WU Cheng-yao XIE Jian-gang QUAN Jing ZHU Li-min
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620,
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
147-151
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）